Search results for " chromatography system"
Article
Making the Move to Continuous Chromatography
Continuous chromatography systems are designed to be loaded continuously, which is a useful approach when the purification step is connected to an upstream perfusion bioreactor. There are several diff…
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Improving Process-Scale Chromatography
Equipment suppliers have also introduced or are developing continuous chromatography systems for use at the lab, pilot, and manufacturing scales. Both Cytiva and Pall have systems based on countercurr…
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Process Chromatography Selection for Downstream Processing Applications
Similarly, if the pump capacity of the chromatography systems is insufficient, a smaller column or a change in the process flow rates may be required. Some of these challenges may be addressed through…
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HT Multi-Product Liquid Chromatography for Characterization of Monoclonal Antibodies
If used correctly, these new analytical methods can reduce analysis and product development time.
ABSTRACT
Monoclonal antibodies represent a significant portion of sales in the biopharma…
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Single-Use for Downstream Chromatography: Benefit or Hindrance?
Single-use in overall bioprocessing
Suppliers of single-use downstream chromatography systems continue to improve the options available to manufacturers, and to examine ways to reduce the number of…
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Reducing Cross-Contamination Risks in Process Chromatography
The main drivers for using single-use chromatography systems are batch size and frequencies, according to Morelli. “It becomes a balance between the total cost of operation and manufacturing agility, …
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A Look at the Affinity Chromatography Landscape
A Look at the Affinity Chromatography Landscape
New ligands are being developed to meet the separation and purification needs of next-gen biologics.
By Cynthia A. Challener
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Technology Innovations Improve Process Chromatography Performance
As technology matures, inefficiencies and process limitations in downstream process chromatography are improved.
By Feliza Mirasol
Selecting an appropriate separation technology fo…
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Optimizing Resin Performance with Disposable Chromatography Solutions
Interestingly, our customers normally purchase a single-use chromatography system before they start using a disposable column. The chromatography system is a long-term commitment to make, whereas a co…
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Continuous Chromatography: Trends, Definitions and Approaches
From the key process parameter perspective, certain technologies already exist that would control continuous chromatography systems based on process data.
The ultimate goal might be to combine d…